In-Vitro and Ex-Vivo Evaluation of Transfersomal Gel of Methotrexate

Methotrexate on its oral and intravenous administration results in unwanted adverse effects. This drawback can be overcome by transdermal delivery because of painless objective for systemic drug administration. Transfersomes are ultra-deformable vesicles with the flexibility to reach deeper tissues skin. The this research work was develop methotrexate transfersomal gel thin film hydration technique, evaluated entrapment efficiency, deformability, mean vesicle size, stability, incorporated into carbopol ease handling skin applicability a longer period retention MTX-TFS & conventional were characterized consistency, transparency, viscosity, pH. Ex-vivo permeation studies performed using abdominal goat release kinetic parameters flux calculated mathematical models. indicate that MTX successfully entrapped (84.77 ± 2.35 %w/w) transfersomes having 240±1.6 nm sizes 27.13±0.7 deformability index. permeated through at rate 28.12±2.58 µg/cm2/hr as compared (10.35±2.14 µg/cm2/ hr). From study, it concluded used possible substitute formulation due 3 times improvement flux.